Assessment of breast cancer surgical margins with multimodal optical microscopy: A feasibility clinical study.

ABSTRACT: Providing surgical margin information during breast cancer surgery is crucial for the success of the procedure. The margin is defined as the distance from the tumor to the cut surface of the resection specimen. The consensus among surgeons and radiation oncologists is that there should be no tumor left within 1 to maximum 2 mm from the surface of the surgical specimen. If a positive margin remains, there is substantial risk for tumor recurrence, which may also result in potentially reduced cosmesis and eventual need for mastectomy. In this paper we report a novel multimodal optical imaging instrument based on combined high-resolution confocal microscopy-optical coherence tomography imaging for assessing the presence of potential positive margins on surgical specimens. Since rapid specimen

SUBMITTER: Scimone MT 

PROVIDER: S-EPMC7877783 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature