Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh A
PROVIDER: S-EPMC7877791 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ghosh Archishman A Zhou Huan-Xiang HX
Angewandte Chemie (International ed. in English) 20200908 47
Biomolecular droplets formed through phase separation have a tendency to fuse. The speed with which fusion occurs is a direct indicator of condensate liquidity, which is key to both cellular functions and diseases. Using a dual-trap optical tweezers setup, we found the fusion speeds of four types of droplets to differ by two orders of magnitude. The order of fusion speed correlates with the fluorescence of thioflavin T, which in turn reflects the macromolecular packing density inside droplets. U ...[more]