Multi-site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos.

ABSTRACT: We conducted a multi-site investigation of genetic determinants of warfarin dose variability in Latinos from the U.S. and Brazil. Patients from four institutions in the United States (n = 411) and Brazil (n = 663) were genotyped for VKORC1 c.-1639G> A, common CYP2C9 variants, CYP4F2*3, and NQO1*2. Multiple regression analysis was used in the U.S. cohort to test the association between warfarin dose and genotype, adjusting for clinical factors, with further testing in an independent cohort of Brazilians. In the U.S. cohort, VKORC1 and CYP2C9 variants were associated with lower warfarin dose (β = -0.29, P < 2.0 × 10^-16 ; β = -0.21, P = 4.7 × 10^-7 , respectively) whereas CYP4F2 and NQO1 variants were associated with higher dose (β = 0.10, P = 2 × 10^-4 ; β = 0.

SUBMITTER: El Rouby N 

PROVIDER: S-EPMC7877858 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature