Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer's disease.

ABSTRACT: Recent functional magnetic resonance imaging studies have demonstrated that moment-to-moment variability in the blood oxygen level-dependent (BOLD) signal is related to age differences, cognition, and symptomatic Alzheimer's disease (AD). However, no studies have examined BOLD variability in the context of preclinical AD. We tested relationships between resting-state BOLD variability and biomarkers of amyloidosis, tauopathy, and neurodegeneration in a large (N = 321), well-characterized sample of cognitively normal adults (age = 39-93), using multivariate machine learning techniques. Furthermore, we controlled for cardiovascular health factors, which may contaminate resting-state BOLD variability estimates. BOLD variability, particularly in the default mode network, was related to cerebros

SUBMITTER: Millar PR 

PROVIDER: S-EPMC7877894 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature