Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies.

ABSTRACT:

Purpose of review

The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. Broadly neutralizing antibodies (bNAbs), the primary targets of HIV-1 vaccine design, have to negotiate this glycan shield. Here, we review the barriers and opportunities that the HIV-1 glycan shield presents for vaccine induction of bNAbs.

Recent findings

Glycan shields can impact the nature of the antibody response and influence the development of neutralization breadth in HIV-1 infections. The architecture of the glycan shield arising from glycan interactions and dynamics have been modeled, and its fine structure, that is, the site-wise glycan heterogeneity, has been determined for some isolates. Althou

SUBMITTER: Wagh K 

PROVIDER: S-EPMC7877895 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature