Hormonal Regulation of Semaphorin 7a in ER⁺ Breast Cancer Drives Therapeutic Resistance.

ABSTRACT: Approximately 70% of all breast cancers are estrogen receptor-positive (ER⁺ breast cancer), and endocrine therapy has improved survival for patients with ER⁺ breast cancer. However, up to half of these tumors recur within 20 years. Recurrent ER⁺ breast cancers develop resistance to endocrine therapy; thus, novel targets are needed to treat recurrent ER⁺ breast cancer. Here we report that semaphorin 7A (SEMA7A) confers significantly decreased patient survival rates in ER⁺ breast cancer. SEMA7A was hormonally regulated in ER⁺ breast cancer, but its expression did not uniformly decrease with antiestrogen treatments. Additionally, overexpression of SEMA7A in ER⁺ cell lines drove increased in vitro growth in the

SUBMITTER: Crump LS 

PROVIDER: S-EPMC7878309 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature