Brief Report: Weight Gain Following ART Initiation in ART-Naive People Living With HIV in the Current Treatment Era.

ABSTRACT:

Objectives

Evaluate differences in weight change by regimen among people living with HIV (PLWH) initiating antiretroviral therapy (ART) in the current era.

Methods

Between 2012 and 2019, 3232 ART-naïve PLWH initiated ≥3-drug ART regimens in 8 Centers for AIDS Research Network of Integrated Clinical Systems sites. We estimated weight change by regimen for 11 regimens in the immediate (first 6 months) and extended (all follow-up on initial regimen) periods using linear mixed models adjusted for time on regimen, interaction between time and regimen, age, sex, race/ethnicity, hepatitis B/C coinfection, nadir CD4, smoking, diabetes, antipsychotic medication, and site. We included more recently approved regimens [eg, with tenofovir alafenamide fumarate (TAF)] only in the immediate

SUBMITTER: Ruderman SA 

PROVIDER: S-EPMC7878311 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature