Intraindividual Variability of Aldosterone Concentrations in Primary Aldosteronism: Implications for Case Detection.

ABSTRACT: Primary aldosteronism is an underdiagnosed cause of hypertension. Although inadequate screening is one reason for underdiagnosis, another important contributor is that clinicians may inappropriately exclude the diagnosis when screening aldosterone concentrations fall below traditionally established thresholds. We evaluated the intraindividual variability in screening aldosterone concentrations and aldosterone-to-renin ratios, and how this variability could impact case detection, among 51 patients with confirmed primary aldosteronism who had 2 or more screening measurements of renin and aldosterone on different days. There were a total of 137 screening measurements with a mean of 3 (range 2-6) per patient. The mean intraindividual variability, expressed as coefficients of variation, was 31%

SUBMITTER: Yozamp N 

PROVIDER: S-EPMC7878320 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature