Age and Sex Differences in the Associations of Pulse Pressure With White Matter and Subcortical Microstructure.

ABSTRACT: Midlife vascular disease increases risk for dementia and effects of vascular dysfunction on brain health differ between men and women. Elevated pulse pressure, a surrogate for arterial stiffness, contributes to cerebrovascular pathology and white matter damage that may advance cognitive aging; however, it remains unclear how associations between pulse pressure and neural integrity differ by sex and age. This study used restriction spectrum imaging to examine associations between pulse pressure and brain microstructure in community-dwelling women (N=88) and men (N=55), aged 56 to 97 (mean, 76.3) years. Restricted isotropic (presumed intracellular), hindered isotropic (presumed extracellular), neurite density, and free water diffusion were computed in white matter tracts and subcortical regi

SUBMITTER: Reas ET 

PROVIDER: S-EPMC7878422 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature