RNA m⁶A Methylation Regulators Subclassify Luminal Subtype in Breast Cancer.

ABSTRACT: RNA N⁶-methyladenosine (m⁶A) methylation is the most prevalent epitranscriptomic modification in mammals, with a complex and fine-tuning regulatory system. Recent studies have illuminated the potential of m⁶A regulators in clinical applications including diagnosis, therapeutics, and prognosis. Based on six datasets of breast cancer in The Cancer Genome Atlas (TCGA) database and two additional proteomic datasets, we provide a comprehensive view of all the known m⁶A regulators in their gene expression, copy number variations (CNVs), DNA methylation status, and protein levels in breast tumors and their association with prognosis. Among four breast cancer subtypes, basal-like subtype exhibits distinct expression and genomic alteration in m⁶

SUBMITTER: Yang L 

PROVIDER: S-EPMC7878528 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature