RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart.

ABSTRACT: Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily determined by heart rate and unsurprisingly this varies in a day-night manner and is higher during the day in the human (anticipating increased day-time demand). Although this is attributed to a day-night rhythm in post-translational ion channel regulation in the heart's pacemaker, the sinus node, by the autonomic nervous system, we investigated whether there is a day-night rhythm in transcription. RNAseq revealed that ~ 44% of the sinus node transcriptome (7134 of 16,387 transcripts) has a significant day-night rhythm. The data revealed the oscillating components of an intrinsic circadian clock. Presumably this clock (or perhaps the master

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7878777 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature