Murine Myeloid Progenitors Attenuate Immune Dysfunction Induced by Hemorrhagic Shock.

ABSTRACT: Hemorrhagic shock induces an aberrant immune response characterized by simultaneous induction of a proinflammatory state and impaired host defenses. The objective of this study was to evaluate the impact of conditionally immortalized neutrophil progenitors (NPs) on this aberrant immune response. We employed a mouse model of hemorrhagic shock, followed by the adoptive transfer of NPs and subsequent inoculation of Staphylococcus aureus to induce pneumonia. We observed that transplant of NPs decreases the proportion of host neutrophils that express programmed death ligand 1 and intercellular adhesion molecule 1 in the context of prior hemorrhage. Following hemorrhage, NP transplant decreased proinflammatory cytokines in the lungs, increased neutrophil migration into the airspaces, and enhance

SUBMITTER: Cohen JT 

PROVIDER: S-EPMC7878835 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature