A Systematic Review of the Effect of N-Acetylcysteine on Serum Creatinine and Cystatin C Measurements.

ABSTRACT:

Introduction

N-acetylcysteine (NAC) is an antioxidant that can regenerate glutathione and is primarily used for acetaminophen overdose. NAC has been tested and used for preventing iatrogenic acute kidney injury or slowing the progression of chronic kidney disease, with mixed results. There are conflicting reports that NAC may artificially lower measured serum creatinine without improving kidney function, potentially by assay interference. Given these mixed results, we conducted a systematic review of the literature to determine whether there is an effect of NAC on kidney function as measured with serum creatinine and cystatin C.

Methods

A literature search was conducted to identify all study types reporting a change in serum creatinine after NAC administration. The primary o

SUBMITTER: Huang JW 

PROVIDER: S-EPMC7879108 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature