Establishing a Case for Anti-complement Therapy in Membranous Nephropathy.

ABSTRACT:

Introduction

Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease characterized by glomerular subepithelial deposits containing IgG. In experimental MN, these deposits activate complement and cause kidney damage. The role of complement in human MN is less clearly defined. To address this, the current study focused on the role of complement in 2 independent primary (p) MN cohorts.

Methods

Glomeruli were isolated by laser capture microdissection and analyzed by mass spectrometry, focusing on complement proteins, from kidney biopsy specimens from a pMN cohort (n = 11) and from normal controls (n = 5). Immunohistological staining of kidney biopsy specimens for comp

SUBMITTER: Ayoub I 

PROVIDER: S-EPMC7879111 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature