Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis.

ABSTRACT:

Introduction

Hyperphosphatemia is associated with increased morbidity and mortality in patients with chronic kidney disease. The aim of this study was to assess whether a meal with high phosphorus content would affect plasma phosphate in the hours that follow among subjects with end-stage kidney disease on peritoneal dialysis.

Methods

This was a single-blinded randomized cross-over trial of 12 subjects on maintenance peritoneal dialysis, in which subjects were randomized to consume a meal with either high or low phosphorus content on 2 separate trial days. On each trial day, plasma phosphate was measured immediately before consumption of the standardized meal and after 1, 2, 3, and 5 hours.

Results

The mean fasting plasma phosphate at baseline was 1.69 ± 0.22 mmol/l.

SUBMITTER: Lundin MT 

PROVIDER: S-EPMC7879124 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature