Risk of Kidney Failure, Death, and Cardiovascular Events After Lower Limb Complications in Patients With CKD.

ABSTRACT:

Objective

Lower limb complications are major adverse events in patients with peripheral artery disease (PAD) and chronic kidney disease (CKD). These complications can lead to morbidity, disability, reduced quality of life, and higher health care costs. We sought to determine how interim lower limb complications modify the subsequent risk of progression to kidney failure, all-cause mortality before kidney failure, and cardiovascular (CV) events in a cohort of patients with CKD stages G3 to G5.

Methods

We performed a retrospective cohort study using patient-level data obtained by linking several administrative databases from Manitoba, Canada. We used Fine and Gray regression models for the primary outcomes of (1) kidney failure adjusted for the competing risk of all-cause mort

SUBMITTER: Li K 

PROVIDER: S-EPMC7879126 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature