Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.

ABSTRACT:

Objectives

To determine the time to CD4 : CD8 ratio normalization among Canadian adults living with HIV in the modern ART era. To identify characteristics associated with ratio normalization.

Patients and methods

Retrospective analysis of the Canadian Observational Cohort (CANOC), an interprovincial cohort of ART-naive adults living with HIV, recruited from 11 treatment centres across Canada. We studied participants initiating ART between 1 January 2011 and 31 December 2016 with baseline CD4 : CD8 ratio <1.0 and ≥2 follow-up measurements. Normalization was defined as two consecutive CD4 : CD8 ratios ≥1.0. Kaplan-Meier estimates and log-rank tests described time to normalization. Univariable and multivariable proportional hazards (PH) models identified factors associated with

SUBMITTER: Zhabokritsky A 

PROVIDER: S-EPMC7879150 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature