Early-pregnancy weight gain and the risk of preeclampsia: A case-cohort study.

ABSTRACT:

Objective

To investigate the association between early-pregnancy weight gain and risk of preeclampsia to inform pregnancy weight gain recommendations.

Study design

We performed a case-cohort study using a hospital database including 80,812 singleton deliveries from Magee-Womens Hospital, Pittsburgh, Pennsylvania (1998-2011). In each of 6 prepregnancy body mass index (BMI) groups, we abstracted serial antenatal weight measurements from the records of up to 339 preeclampsia cases and 1254 randomly selected pregnancies. Early gestational weight gain (16-19 weeks' gestation) was standardized for gestational duration using BMI-specific z-score charts. Multivariable log-binomial regression was used to assess the association between weight gain z-score and risk of preeclampsia. We

SUBMITTER: Bodnar LM 

PROVIDER: S-EPMC7879463 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature