Altered local and matrix functional connectivity in depressed essential tremor patients.

ABSTRACT:

Background

Depression in essential tremor (ET) has been constantly studied and reported, while the associated brain activity changes remain unclear. Recently, regional homogeneity (ReHo), a voxel-wise local functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided a promising way to observe spontaneous brain activity.

Methods

Local FC analyses were performed in forty-one depressed ET patients, 49 non-depressed ET patients and 43 healthy controls (HCs), and then matrix FC and clinical depression severity correlation analyses were further performed to reveal spontaneous neural activity changes in depressed ET patients.

Results

Compared with the non-depressed ET patients, the depressed ET patients showed decreased ReHo in

SUBMITTER: Duan X 

PROVIDER: S-EPMC7879612 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature