The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis.

ABSTRACT:

Background

This study aimed to investigate the effect of abnormal Core binding factor-β expression on proliferation, differentiation and apoptosis of chondrocytes, and elucidate the relationship between Core binding factor-β and osteoarthritis-related markers and degenerative joint disease.

Methods

Cartilage tissues, from healthy subjects and patients with osteoarthritis, were collected for histology and expression of Core binding factor-β, MMP-13, IL-1β, COMP, and YKL-40. Human articular chondrocytes were cultured in vitro, and a viral vector was constructed to regulate cellular Core binding factor-β expression. Cellular proliferation and apoptosis were observed, and osteoarthritis-related inflammatory factor expression and cartilage metabolite synthesis assayed.

Results

SUBMITTER: Li G 

PROVIDER: S-EPMC7879671 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature