Optimal experimental design for mathematical models of haematopoiesis.

ABSTRACT: The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells. It is known that feedback regulation is crucial to tightly control this system, but the specific mechanisms by which control is exerted are not completely understood. In this work, we aim to uncover the underlying mechanisms in haematopoiesis by conducting perturbation experiments, where animal subjects are exposed to an external agent in order to observe the system response and evolution. We have developed a novel Bayesian hierarchical framework for optimal design of perturbation experiments and proper analysis of the data collected. We use a deterministic model that accounts for feedback and feedforward regulation on cell division rates

SUBMITTER: Lomeli LM 

PROVIDER: S-EPMC7879761 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature