Bioinspired Nanoparticles Engineered for Enhanced Delivery to the Bone.

ABSTRACT: Targeting therapeutic agents to specific organs in the body remains a challenge despite advances in the science of systemic drug delivery. We have engineered a programmable-bioinspired nanoparticle (P-BiNP) delivery system to simultaneously target the bone and increase uptake in homotypic tumor cells by coating polymeric nanoparticles with programmed cancer cell membranes. This approach is unique in that we have incorporated relevant clinical bioinformatics data to guide the design and enhancement of biological processes that these nanoparticles are engineered to mimic. To achieve this, an analysis of RNA expression from metastatic prostate cancer patients identified ITGB3 (a subunit of integrin α _V β ₃) as overexpressed in patients with bone metastasis.

SUBMITTER: Gdowski AS 

PROVIDER: S-EPMC7880042 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature