Remotely delivered environmental enrichment intervention for traumatic brain injury: Study protocol for a randomised controlled trial.

ABSTRACT:

Introduction

Individuals with moderate-severe traumatic brain injury (m-sTBI) experience progressive brain and behavioural declines in the chronic stages of injury. Longitudinal studies found that a majority of patients with m-sTBI exhibit significant hippocampal atrophy from 5 to 12 months post-injury, associated with decreased cognitive environmental enrichment (EE). Encouragingly, engaging in EE has been shown to lead to neural improvements, suggesting it is a promising avenue for offsetting hippocampal neurodegeneration in m-sTBI. Allocentric spatial navigation (ie, flexible, bird's eye view approach), is a good candidate for EE in m-sTBI because it is associated with hippocampal activation and reduced ageing-related volume loss. Efficacy of EE requires intensive daily training

SUBMITTER: Belchev Z 

PROVIDER: S-EPMC7880099 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature