First-phase ejection fraction: association with remodelling and outcome in aortic valve stenosis.

ABSTRACT:

Background

First-phase ejection fraction (EF1), the left ventricular (LV) ejection fraction (EF) until the time of peak transaortic velocity, is a novel marker of subclinical LV dysfunction able to predict adverse events in aortic stenosis (AS). This study investigated the association between end-systolic wall stress (ESWS) and EF1 in severe AS, as well as the prognostic value of EF1 in severe asymptomatic AS.

Methods

Two prospectively gathered cohorts of 94 asymptomatic patients and 108 symptomatic patients scheduled for aortic valve replacement (AVR), all with severe AS (aortic valve area <1 cm²) were stratified according to the median value of EF1 (33%). EF1 was defined as the EF at peak transaortic velocity. Asymptomatic patients were followed up for 3 years f

SUBMITTER: Carter-Storch R 

PROVIDER: S-EPMC7880107 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature