B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8⁺ T cells in pancreatic cancer.

ABSTRACT: Beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) has been associated with tumor progression in several solid tumors, and inhibits CD8⁺ T cell-mediated anti-tumor immunity in breast cancer. However, little is known about the potential functions of B3GNT3 in immunosuppression in pancreatic cancer (PC). This study on B3GNT3 aims to provide novel insights into the mechanisms of immune suppression or evasion in PC. To this end, the clinical significance and oncologic roles of B3GNT3 were investigated through bioinformatic analysis and in vitro studies. Potential associations between the expression of B3GNT3 and tumor immunity were mainly analyzed by single-sample gene set enrichment analysis (ssGSEA) and immunofluorescence in tissue

SUBMITTER: Zhuang H 

PROVIDER: S-EPMC7880340 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature