Serum response factor, a novel early diagnostic biomarker of acute kidney injury.

ABSTRACT:

Objective

Studies have shown that serum response factor (SRF) is increased in chronic kidney injury, such as diabetic nephropathy, hyperuricemic nephropathy and renal cell carcinoma. The objective is to explore the early diagnostic value of SRF in acute kidney injury (AKI).

Methods

AKI-related microarray data were analyzed, and the expression and location of SRF were investigated in the early phase of AKI.

Results

Bioinformatics results demonstrated that SRF was dramatically elevated 2-4 h after ischemia/reperfusion (I/R) in mouse renal tissue. In I/R rats, SRF was mostly expressed and located in renal tubular epithelial cells (TECs). SRF started to increase at 1 h, peaked at 3-9 h and started to decrease at 12 h after I/R. The areas under the ROC curve of renal SRF m

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7880358 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature