The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice.

ABSTRACT: Histone modifications, specifically in the lysine residues of histone H3, have been implicated in lifespan regulation in several model organisms. Our previous studies showed that growth hormone (GH) treatment during early life can dramatically influence lifespan in long-lived Ames dwarf mice. However, the effects of this hormonal intervention on epigenetic modifications have never been examined. In this study, we sought to compare tissue-specific histone H3 lysine methylation and acetylation markers in Ames dwarf and wild type (WT) mice and to determine how these markers are affected by early-life GH intervention. Ames dwarf mice exhibited suppressed H3K4me in both hepatic and brain tissues, while showing elevated H3K27me in the brain. Early-life GH intervention significantly altered the h

SUBMITTER: Zhang F 

PROVIDER: S-EPMC7880366 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature