Estimation of time of HIV seroconversion using a modified CD4 depletion model.

ABSTRACT:

Introduction

Several methods have been proposed to estimate the time of HIV seroconversion, including those based on CD4 cell depletion models. However, previous models have failed to consider the heterogeneity that exists in CD4 trajectories among different sub-populations. Our objective was to estimate the time from HIV seroconversion relative to the HIV diagnosis date in a population-based cohort of people living with HIV (PLWH) in the province of British Columbia, Canada.

Methods

We used linked administrative and clinical data from the British Columbia Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) cohort, which contains longitudinal individual-level data on all PLWH ever diagnosed in the province. Eligible participants were aged ≥18 years and diagnose

SUBMITTER: Lima VD 

PROVIDER: S-EPMC7880448 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature