Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.

ABSTRACT: Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau pathology, although the underlying mechanism remains elusive. Here, for the first time, we comprehensively characterized the physicochemical structure and pathogenic function of human brain-derived extracellular vesicles isolated from Alzheimer's disease, prodromal Alzheimer's disease, and non-demented control cases. Alzheimer's disease extracellular vesicles were significantly enriched in epitope-specific tau oligomers in comparison to prodromal Alzheimer's disease or control extracellular vesicles as determined by dot blot and atomic force microscopy. Alzheimer's disease extracellular vesicles were more efficiently internalized by murine cortical neurons, as well as more efficient in transfe

SUBMITTER: Ruan Z 

PROVIDER: S-EPMC7880668 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature