Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment.

ABSTRACT: Epilepsy incidence and prevalence peaks in older adults yet systematic studies of brain ageing and cognition in older adults with epilepsy remain limited. Here, we characterize patterns of cortical atrophy and cognitive impairment in 73 older adults with temporal lobe epilepsy (>55 years) and compare these patterns to those observed in 70 healthy controls and 79 patients with amnestic mild cognitive impairment, the prodromal stage of Alzheimer's disease. Patients with temporal lobe epilepsy were recruited from four tertiary epilepsy surgical centres; amnestic mild cognitive impairment and control subjects were obtained from the Alzheimer's Disease Neuroimaging Initiative database. Whole brain and region of interest analyses were conducted between patient groups and controls, as well as bet

SUBMITTER: Kaestner E 

PROVIDER: S-EPMC7880670 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature