Towards early disease modification of Parkinson's disease: a review of lessons learned in the Alzheimer field.

ABSTRACT: Parkinson's disease (PD) research is beginning to focus on early disease modification and prevention. The therapeutic pipeline includes a growing range of pharmacological interventions that could theoretically intervene with the underlying disease process. It is hoped that applying such interventions in a very early stage of the disease pathology, before the onset of motor symptoms or during its early stages, may prevent or delay further disease progression. To identify people in this early disease stage, criteria for 'prodromal PD' have been proposed-describing people with one or more specific features that jointly constitute a variably increased risk of developing clinically manifest PD. Here, we aim to draw lessons from the field of Alzheimer's research, which has followed a similar str

SUBMITTER: Smedinga M 

PROVIDER: S-EPMC7880921 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature