MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas.

ABSTRACT:

Objectives

To assess the combined role of tumor vascularity, estimated from perfusion MRI, and MGMT methylation status on overall survival (OS) in patients with glioblastoma.

Methods

A multicentric international dataset including 96 patients from NCT03439332 clinical study were used to study the prognostic relationships between MGMT and perfusion markers. Relative cerebral blood volume (rCBV) in the most vascularized tumor regions was automatically obtained from preoperative MRIs using ONCOhabitats online analysis service. Cox survival regression models and stratification strategies were conducted to define a subpopulation that is particularly favored by MGMT methylation in terms of OS.

Results

rCBV distributions did not differ significantly (p > 0.05) in the methylat

SUBMITTER: Fuster-Garcia E 

PROVIDER: S-EPMC7880975 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature