Ontology highlight
ABSTRACT:
SUBMITTER: Ribeiro MFSA
PROVIDER: S-EPMC7880994 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ribeiro Maurício Fernando Silva Almeida MFSA Knebel Franciele Hinterholz FH Bettoni Fabiana F Saddi Rodrigo R Sacardo Karina Perez KP Canedo Felipe Sales Nogueira Amorim FSNA Alessi João Victor Machado JVM Shimada Andrea Kazumi AK Marin José Flávio Gomes JFG Camargo Anamaria Aranha AA Katz Artur A
NPJ precision oncology 20210212 1
The survival outcomes of the FLAURA trial support osimertinib as the new standard of care for untreated patients harboring activating mutations in the epidermal growth factor receptor (EGFR). Despite the initial response, disease progression invariably occurs. Although uncommon, BRAF V600E mutation arises as a unique mechanism of resistance, and thus far, no prospective studies are available to support concurrent EGFR/BRAF blockade. We report a case of impressive radiological and ctDNA response ...[more]