Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.

ABSTRACT:

Background

Family history of prostate cancer (PCa) is a well-known risk factor, and both common and rare genetic variants are associated with the disease.

Objective

To detect new genetic variants associated with PCa, capitalizing on the role of family history and more aggressive PCa.

Design, setting, and participants

A two-stage design was used. In stage one, whole-exome sequencing was used to identify potential risk alleles among affected men with a strong family history of disease or with more aggressive disease (491 cases and 429 controls). Aggressive disease was based on a sum of scores for Gleason score, node status, metastasis, tumor stage, prostate-specific antigen at diagnosis, systemic recurrence, and time to PCa death. Genes identified in stage one were scre

SUBMITTER: Schaid DJ 

PROVIDER: S-EPMC7881048 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature