Is There Any Need for Adjusting ¹³¹I Activity for the Treatment of High Turnover Graves' Disease Compared to Normal Turnover Patients? Results from a Retrospective Cohort Study Validated by Propensity Score Analysis.

ABSTRACT:

Purpose

To compare ¹³¹I-therapy outcomes in high turnover and normal turnover Graves' disease patients and predict optimal first ¹³¹I activity for high turnover patients.

Methods

Retrospective cohort design (1:2) validated by propensity score analysis. Cohort 1, high turnover (2-h RAIU/24-h RAIU ≥ 1), n = 104, and cohort 2, normal turnover (ratio < 1), n = 208, patients were compared for post ¹³¹I outcome. The cure was defined as a combined euthyroid and stable hypothyroid state following ¹³¹I treatment. Logistic regression analysis was used for identifying prognostic factors. The propensity score was applied; 77 matched pairs (1:1 ratio) of high and normal turnover patients were selected as a validation set.

Resul

SUBMITTER: Arora S 

PROVIDER: S-EPMC7881070 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature