Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma.

ABSTRACT: Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution remained unknown. By long-term tracking of tumor cell fate and dynamics in the live mouse brain, differential therapeutic responses in both niches are determined. Both the PVN, a preferential location of long-term quiescent glioma cells, and network integration facilitate resistance against cytotoxic effects of radiotherapy and chemotherapy-independently of each other, but with additive effects. Perivascular glioblastoma cells are particularly able to actively repair damage to tumor regions. Population of the PVN and resistance in it depend on proficient NOTCH1 expressio

SUBMITTER: Jung E 

PROVIDER: S-EPMC7881116 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature