Exploring the mechanism of aidi injection for lung cancer by network pharmacology approach and molecular docking validation.

ABSTRACT:

Background

Aidi injection (ADI) is an effective Traditional Chinese medicine preparation widely used for lung cancer. However, the pharmacological mechanisms of ADI on lung cancer remain to be elucidated.

Methods

A network pharmacology (NP)-based approach and the molecular docking validation were conducted to explore underlying mechanisms of ADI on lung cancer. The compounds and target genes were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (Batman-TCM) database. The STRING database was utilized for protein interaction network construction. The R package clusterProfiler was used for bioinformatics annotation of hub target genes. The gene expression analy

SUBMITTER: Zhuang Z 

PROVIDER: S-EPMC7881165 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature