Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis.

ABSTRACT: Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.

SUBMITTER: Hachiya T 

PROVIDER: S-EPMC7881200 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature