The IL-27 receptor regulates TIGIT on memory CD4⁺ T cells during sepsis.

ABSTRACT: Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD-1, we assessed whether IL-27 impacts these co-inhibitory molecules in sepsis. Based on these data, we hypothesized that IL-27 was responsible for T cell dysfunction during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we found that IL-27Rα was associated with the upregulation of TIGIT on memory CD4⁺ T cells following CLP. However, IL-27 was not associated with sepsis mortality.

SUBMITTER: Morrow KN 

PROVIDER: S-EPMC7881227 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature