The Role of Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology.

ABSTRACT:

Purpose

We previously identified three microRNAs (miRNAs) with significantly increased expression in the serum of patients with age-related macular degeneration (AMD) compared with healthy controls. Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. We also aim to demonstrate the pathologic role of isolated sera-derived exosomes from patients with AMD and controls using in vitro models.

Methods

miR-19a, miR-126, and miR-410 were investigated using bioinformatic approaches, including DIANA-mirPath and miR TarBase. Data on the resulting target genes and signaling pathways

SUBMITTER: ElShelmani H 

PROVIDER: S-EPMC7881277 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature