Endometrial regeneration with endometrial epithelium: homologous orchestration with endometrial stroma as a feeder.

ABSTRACT:

Background

Thin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium; however, endometrial epithelial cells have limited expansion potential, which needs to be overcome in order to make regenerative medicine a therapeutic strategy for refractory thin endometrium. Here, we aimed to perform long-term culture of endometrial epithelial cells in vitro.

Methods

We prepared primary human endometrial epithelial cells and endometrial stromal cells and investigated whether endometrial stromal cells and human embryonic stem cell-derived feeder cells could support proliferation of endometrial epithelial cells. We also investigated whethe

SUBMITTER: Yokomizo R 

PROVIDER: S-EPMC7881492 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature