Sex-related differences in brain dynamism at rest as neural correlates of positive and negative valence system constructs.

ABSTRACT: Clinical anxiety and depression are the most prevalent mental illnesses, likely representing maladaptive expressions of negative valence systems concerned with conditioned responses to fear, threat, loss, and frustrative nonreward. These conditions exhibit similar, striking sex/gender-related differences in onset, incidence, and severity for which the neural correlates are not yet established. In alarge sample of neurotypical young adults, we demonstrate that intrinsic brain dynamism metrics derived from sex-sensitive models of whole-brain network function are significantly associated with valence system traits. Surprisingly, we found that greater brain dynamism is strongly positively correlated to anxiety and depression traits in males, but almost wholly decoupled from traits for importan

SUBMITTER: de Lacy N 

PROVIDER: S-EPMC7881523 | biostudies-literature | 2021 Jul-Oct

REPOSITORIES: biostudies-literature