Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is characterized by β-cell dysfunction as a result of impaired glucose-stimulated insulin secretion (GSIS). Studies show that β-cell circadian clocks are important regulators of GSIS and glucose homeostasis. These observations raise the question about whether enhancement of the circadian clock in β-cells will confer protection against β-cell dysfunction under diabetogenic conditions. To test this, we used an approach by first generating mice with β-cell-specific inducible overexpression of Bmal1 (core circadian transcription factor; β-Bmal1 ^OV ). We subsequently examined the effects of β-Bmal1 ^OV on the circadian clock, GSIS, islet transcriptome, and glucose metabolism in the context of diet-induced ob

SUBMITTER: Rakshit K 

PROVIDER: S-EPMC7881843 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature