The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs.

ABSTRACT: Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known for over 120 years, these small molecules continue to challenge our assumptions about biosynthetic pathways, catalyze our creativity for constructing complex architectures, and embolden new approaches for treating mental illness. This review will cover recent advances in both the biosynthesis and chemical synthesis of iboga alkaloids as well as their use as next-generation neurotherapeutics. Whenever appropriate, we provide historical context for the discoveries of the past d

SUBMITTER: Iyer RN 

PROVIDER: S-EPMC7882011 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature