Brain features of nearly drug-naive female monozygotic twins with first-episode schizophrenia and the classification accuracy of brain feature patterns: A pilot study.

ABSTRACT:

Background

Data on differences in brain features between monozygotic (MZ) twins with and without schizophrenia are scarce.

Methods

We compared brain features of female MZ twins with and without first-episode schizophrenia and healthy controls (n = 20 each). Voxel-based morphometry and tract-based spatial statistics were used to analyze differences in brain structure. Whole-brain effective connectivity (EC) and functional connectivity (FC) networks were constructed using resting-state functional magnetic resonance imaging (rs-fMRI) data.

Results

Female twins with schizophrenia exhibited abnormal gray matter volume (GMV) in the basal ganglia and prefrontal and parietal cortices, impairments in the arcuate fasciculus, and significant disruptions (primarily decreases) in

SUBMITTER: Zhang T 

PROVIDER: S-EPMC7882158 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature