Microstructural white matter abnormalities in pediatric and adult obsessive-compulsive disorder: A systematic review and meta-analysis.

ABSTRACT:

Objective

To identify the most prominent and replicable fractional anisotropy (FA) alterations of white matter associated with obsessive-compulsive disorder (OCD) in tract-based spatial statistics (TBSS) studies.

Methods

We reviewed previous TBSS studies (n = 20) in OCD and performed a meta-analysis (n = 16) of FA differences.

Results

No between-group differences in FA were detected in the pooled meta-analysis. However, reduced FA was identified in the genu and anterior body of corpus callosum (CC) in adult OCD. FA reductions in the anterior body of CC were associated with a later age of onset in adult patients with OCD. For pediatric OCD, decreased FA in earlier adolescence and increased FA in later adolescence were seemingly related to an altered trajectory of brain

SUBMITTER: Li Q 

PROVIDER: S-EPMC7882176 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature