Revitalizing the common peroneal function index for assessing functional recovery following nerve injury.

ABSTRACT:

Background and aims

Peripheral nerve injury is common with poor functional recovery and consequent high personal and societal costs. Sciatic nerve transection and assessment of recovery using sciatic functional index (SFI) are widely used. SFI is biologically limited as axonal misdirection of axons supplying flexors and extensors in the hindlimb, after nerve injury can lead to synkinetic innervation and function which does not correspond to the degree of axonal regeneration.

Methods

We reevaluated the use of traditional metrics such as print length (PL), toe spread (TS), and intermediate toe spread (ITS) as well as hock angle at mid-swing as approaches for determining recovery. We used two alternative approaches in discrete cohorts of rats following common peroneal crush inj

SUBMITTER: Fontaine C 

PROVIDER: S-EPMC7882187 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature