Treatment for comorbid depressive disorder or subthreshold depression in diabetes mellitus: Systematic review and meta-analysis.

ABSTRACT:

Objective

To provide an estimate of the effect of interventions on comorbid depressive disorder (MDD) or subthreshold depression in type 1 and type 2 diabetes.

Methods

Systematic review and meta-analysis. We searched PubMed, PsycINFO, Embase, and the Cochrane Library for randomized controlled trials evaluating the outcome of depression treatments in diabetes and comorbid MDD or subthreshold symptoms published before August 2019 compared to care as usual (CAU), placebo, waiting list (WL), or active comparator treatment as in a comparative effectiveness trial (CET). Primary outcomes were depressive symptom severity and glycemic control. Cohen's d is reported.

Results

Forty-three randomized controlled trials (RCTs) were selected, and 32 RCTs comprising 3,543 patients wer

SUBMITTER: van der Feltz-Cornelis C 

PROVIDER: S-EPMC7882189 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature