Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model.

ABSTRACT: One of the most prevalent joint disorders in the United States, osteoarthritis (OA) is characterized by progressive degeneration of articular cartilage, primarily in the hip and knee joints, which results in significant impacts on patient mobility and quality of life. To date, there are no existing curative therapies for OA able to slow down or inhibit cartilage degeneration. Presently, there is an extensive body of ongoing research to understand OA pathology and discover novel therapeutic approaches or agents that can efficiently slow down, stop, or even reverse OA. Thus, it is crucial to have a quantitative and reproducible approach to accurately evaluate OA-associated pathological changes in the joint cartilage, synovium, and subchondral bone. Currently, OA severity and progression are

SUBMITTER: Pinamont WJ 

PROVIDER: S-EPMC7882241 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature