Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children.

ABSTRACT:

Background

Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, WTAP has been reported as an independent prognostic factor in patients with neuroblastoma.

Methods

To explore the association between three WTAP polymorphisms (rs9457712 G>A, rs1853259 A>G and rs7766006 G>T) and neuroblastoma susceptibility in Chinese populations, we performed this case-control study including 898 neuroblastoma cases and 1,734 controls. We genotyped these potentially functional single nucleotide polymorphisms (SNPs) by TaqMan assays. The odds ratios (ORs) and 95% confidence intervals (CIs) by logistic regression models were used to assess the relationship between WTAP SNPs and the risk of neuroblastoma.

Results

No significant association

SUBMITTER: Tang J 

PROVIDER: S-EPMC7882302 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature